Lose Fat With Science-Based Tools | Huberman Lab Essentials

Welcome to Huberman Lab Essentials, where we revisit past episodes for the most potent and actionable science-based tools for mental health, physical health, and performance. I'm Andrew Huberman, and I'm a professor of neurobiology and ophthalmology at Stanford School of Medicine. This podcast is separate from my teaching and research roles at Stanford. It is,

however, part of my desire and effort to bring zero-cost consumer information about science and science-related tools to the general public. Today, we're going to talk about the science of tools for fat loss. Today's episode is mainly going to be focused on how the nervous system, neurons, and some of the cells they collaborate with, like glia and

macrophages, how those encourage or can encourage accelerated fat loss, because it turns out they can. Remember, your nervous system, which includes your brain and your spinal cord, and all the connections that they make with the organs of the body, governs everything. The nervous system and the role of the brain and other neurons has been vastly overlooked in

the discussion about losing fat. Now, I would be remiss, and I'd probably come under a pretty considerable attack if I didn't just acknowledge up front a core truth of metabolic science and also of neuroscience, frankly, which is that calories in versus calories out, meaning how many calories you ingest versus how many calories you burn, is the

fundamental and most important formula in this business of fat loss and weight management in general. There's simply no way around the fact that if you ingest far more calories than you burn, you're likely to gain weight. And a good portion of that weight is likely to be adipose tissue, fat. It's also true that if you ingest fewer