Fed State | Insulin & Role of Liver | Blood Glucose Regulation Part 2/2🧑🏻‍⚕️

hello let's continue with our discussion and in previous lecture we just talked about that there is a portal vein and this hepatic vein they are going to the liver and blood while blood is passing through the liver that is blood is blood and its content are exposed to the hepatocyte and after that blood drains into hepatic veins and eventually into inferior vena cava and

systemic circulation right so we can say this is portal circulation this is systemic circulation in between we have put liver now i put here one hepatocyte and that's hepatocyte i've drawn in a mega form here in a big form here so let's see here on the hepatocyte how our hepatocyte works on the glucose right first of all let's suppose on this hepatocyte here is

circulatory system and it is having nutrients as i said it is bringing nutrients including its bringing glucose right and it is also bringing insulin c peptide and keratins and other substances now there are two things first of all i will talk about insulin how insulin work how insulin works as you know that insulin is a peptide hormone

because it is a peptide hormone so it is long or big molecule and of course amino acids many of them are charged so it is big molecule and somewhat charged molecule so insulin molecule cannot enter into membranes because insulin molecule cannot cross the membranes of the cell the first thing we need to learn is that insulin receptors are present on the membrane not within

the cell why because insulin cannot enter into cell by dissolving into plasma membranes now let me draw the insulin receptor first of all and how the insulin system works right insulin receptor basically consists of two alpha units alpha units and attached with them there are these two beta units now alpha units and beta units all of them are held together by disulfide bond let me